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KMID : 0903520000430020153
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2000 Volume.43 No. 2 p.153 ~ p.157
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Effect of Chlorogenic Acid on the Concentrations of Serum and Hepatic Lipid in Rats
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Abstract
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Effect of chlorogenic acid, one of polyphenolic compounds, on the concentrations of lipid in serum and hepatic lipid, serum glucose, and urinary protein in Sprague Dawley rats for 14 days was investigated. The concentration of serum total cholesterol was increased in the cholesterol group compared with the control group, while it was decreased in the cholesterol+chlorogenic acid group. The concentrations of hepatic triacylglycerol and cholesterol were increased in the cholesterol group, while these were not altered by the supplementation of chlorogenic acid. The concentrations of serum glucose and urinary protein were higher in the cholesterol+chlorogenic acid group than the control and the cholesterol groups. These results suggest that chlorogenic acid exerts a hypocholesterolemic effect in the rats fed cholesterol.
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